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Genetic variants decreasing SOD2 activity have links to depression
This is the mechanism most people recognize from medications like Ozempic and Wegovy
Ozempic tends to lower fasting numbers by 25-30 mg/dL on average, while Trulicity typically achieves 20-25 mg/dL reductions
It mimics GLP-1, acting on appetite-regulating areas of the brain to reduce hunger and increase satiety (MHRA, 2026)
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