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Wie Kojima und Kangawa, 2005 fuer das gesamte Ghrelin-System darlegen, aktiviert der besetzte Rezeptor die Phospholipase C (PLC), die Inositoltrisphosphat (IP3) freisetzt

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Clinical translation requires human CSF pharmacokinetic assays to prove BBB bypass, a rigorous dose-escalation Phase I trial to establish a safe human NOAEL for chronic dosing, and an RCT utilizing precise neurocognitive testing (e.g., MoCA) to confirm that murine transcriptomic shifts yield functional neuroprotection in humans

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Peripheral vascular thrombosis has also occurred

doi: 10.1038/sj.bjp.0706912 123 BrhlHCihakJPlachJKunz-SchughartLNiedermeierMDenzelAet al