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STEP UP Trial This newer study used a higher dose (7.2 mg)

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Treatments with the NOS inhibitor L-NAME and iNOS inhibitor GW274150 are proven to improve inflammation response, and a trend toward a reduction in synovial thickness is observed (154, 155)

GLP-1 receptor agonists may offer a new approach that can complement existing topical, systemic and biologic treatment options. Across the trials, clinicians treated participants with one of three GLP-1s 81.5% received semaglutide (Wegovy, Novo Nordisk), 17.4% received liraglutide and 1% received tirzepatide (Zepbound, Eli Lilly) at varying dosages and treatment durations

GLP-1R activation also inhibits NF-B activation through the cAMP/PKA signaling pathway, suppressing inflammatory and angiogenic gene expression in retinal cells, including VEGF