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Metabolic flexibility Although glutamine is the primary carbon source for the TCA cycle in some cancer cells, replenishment of TCA cycle intermediates using alternative anaplerotic substrates reduces bioenergetic stress, thereby enabling resistance to inhibition of glutamine metabolism

Therefore, an opportunity may present itself to ameliorate ARTHS by treatment increasing histone acetylation in individuals with a reduction in histone acetylation

In this biosynthesis process, methionine is a critical source of cysteine to synthesize glutathione through methionine adenosyltransferase, S-adenosylhomocysteine hydrolase, cystathionine -synthase, cystathionine -lyase, GS, and so on [32]

Cham: Springer International Publishing (2024)

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Imbalance in the OPG and RANKL properties is directly associated with the differentiation and activity of osteoclasts and favors bone resorption