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doi: 10.1007/s40264-020-00953-0 46 MukhtarI.AnwarH.HussainG.RasulA.NaqviS

The genes for inhibitors of the cell cycle (CDKN1, CDKN4D and ATM) are induced, whereas cyclins (proliferating cell nuclear antigen (PCNA), cyclin A, cyclin D1 and cyclin K) are downregulated during the period from 6 to 20 h [14]

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TB-500 dosing follows a loading phase of 2mg twice weekly for 4 weeks, followed by a maintenance dose of 2mg weekly