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Within the proximal tubule epithelial cell apical membrane and basolateral membrane, H + and HCO 3 transporters and extracellular and intracellular carbonic anhydrases (CAIV and CAII, respectively) are involved in the processes of acid-base regulation within this segment of the nephron

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Data in the literature suggests that TNBC is more susceptible to ferroptosis compared to ER+ breast cancer

Simultaneously, various GPX4-independent enzymes contribute to ferroptosis resistance in distinct cellular compartments (Fig