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The latter is a structure formed by the local rearrangement of host cytoskeleton enriched in the aforementioned proteins that gives the bacterium an anchoring point and enables the triggering of the signaling required for meningococcal internalization (Merz et al., 1999)

Loss of PPAR function in hepatocytes initiates DNA hypermethylation of genes related to fatty acid, bile acid, and steroid hormone receptors, including PPAR, leading to progression of disease [339]

During this process, O 2 produced by the mitochondrial tricarboxylic acid (TCA) cycle and the reduction of nitrogen oxides by NADPH produce H 2 O 2 catalyzed by superoxide dismutase (SOD) and participate in the Fenton reaction of iron (26) ( Figure 1A )

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Long-term outcomes depend on continued medication use

The effect appears mediated by improved blood flow and local growth factor signaling