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Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring neuropeptide first identified in the 1970s during studies on sleep regulation in rabbits

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5 Despite the fact that the pathological characteristics of OA involve impairment of the entire joint structure, including remodeling of subchondral bone, osteophyte formation, and synovial inflammation, 6 the primary pathological hallmark remains cartilage damage

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Therapeutic combination strategies involving polyphenols The combined use of polyphenols can produce a synergistic effect, significantly enhancing the treatment of neurodegenerative diseases [254]