In clinical studies, patients who paired medication with a balanced diet and activity reached significant weight loss over months, not days
Common side effects during the early weeks include: Nausea (the most frequently reported) Reduced appetite Mild abdominal discomfort or bloating Occasional diarrhoea or constipation These effects are usually mild to moderate and tend to diminish as the body adapts to the medication
Be consistent: Take your injection on the same day each week
Also consider keeping a journal of your meals and side effects
For patients managing type 2 diabetes, inconsistent dosing may lead to poor blood sugar control and increased risk of complications
Recent studies have found that increased level of GLP-1 in the hippocampus restores GABA and reverses this neurotoxic effect by reducing oxidative stress through the SIRT1/Nrf2/HO-1 pathway, promoting autophagy through the AMPK/mTOR pathway, and alleviating hippocampal apoptosis by inactivating pro-apoptotic kinase GSK-3 ( The anorectic effects of GLP-1 can also be explained by its GABAergic modulation in the nucleus tractus solitarius (NTS) cells
