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Simultaneously, NNMT inhibition preserves SAM the primary methyl-donor for epigenetic histone and DNA methylation reactions which has been shown to influence gene expression programmes governing adipogenesis, lipid storage, and energy expenditure in adipose tissue models

GSH is a non-enzymatic antioxidant, is an antioxidant synthesized by cells, and serves as a reversible oxygen donor through the conversion of the oxidation-reduction state of sulfhydryl groups, and mainly provides oxidation protection in the water phase in cells

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Kumar P, Liu C, Suliburk J, Hsu JW, Muthupillai R, Jahoor F, Minard CG, Taffet GE, Sekhar RV