The studies that were cited as supportive of the obesity paradox did not differentiate intentional and unintentional weight loss and were observational rather than randomized
While there's always the low-hanging fruit option of buying clothes at Goodwill or just letting baggy trends take over, I also found Jennifer Hardy Dec 8, 20256 min read The Ultimate 2025 Gift Guide for GLP-1 Users At least one in ten Americans uses a GLP-1 like Wegovy or Zepbound
Gasiorowska A, Wydrych M, Drapich P, Zadrozny M, Steczkowska M, Niewiadomski W, Niewiadomska G (2021) The biology and pathobiology of glutamatergic, cholinergic, and dopaminergic signaling in the aging brain
Wegovy should never be considered as a quick-fix solution
The Mayo Clinic data suggests you may see up to 35% more weight loss than you would with tirzepatide alone, a difference that becomes increasingly significant over time
These effects are associated with the drug's mechanism of action on the gastrointestinal tract