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Most of the clinical studies showing measurable effects ran for 4-6 months

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Billings LK, Hsia S, Bays H, et al

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Although inflammation can be a protective response, sustained activation of neuroinflammatory pathways leads to neuronal injury and causes the progression of neurodegenerative disorders (Adamu et al., 2024)

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[79] A phase I trial of intravenous vitamin E in treatment refractory neuroblastoma found mild toxicity (tendency toward increased bleeding time was noted) at doses below 2,300 mg/m2

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Bone Min

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