Given his history of previously controlled diabetes without improvement of psoriasis and improvement of psoriatic lesions prior to weight loss while being treated with liraglutide, the improvement in his psoriasis was likely due to a mechanism other than weight reduction or glycemic control
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Jones GD, Droz B, Greve P, et al
10.1016/j.peptides.2020.170419 24 KimS
Key findings include: Upregulation of VEGFR2 expression and internalization in endothelial cells Activation of the VEGFR2-Akt-eNOS signaling cascade Enhanced endothelial cell proliferation and tube formation Improved collateral circulation in ischemic injury models The peptides pro-angiogenic effects appear particularly relevant in healing scenarios where blood supply restoration is critical for tissue recovery
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