The expression of GLS-2 is also positively regulated by wild-type TP53 , as such the conversion of glutamine-to-glutamate increases, which is requisite for supplement of NADPH and GSH (172, 173)
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Except for the presence of two AT-hooks possibly involved in DNA binding 16,17 , the C-terminal quarter of the protein is predicted to be mostly disordered and remains poorly characterized 18,19