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Subsequently, the hypothalamus-anterior pituitary gland axis is suppressed due to the negative feedback mechanism
The gene expression changes the peptide triggers may be more important than continuous peptide presence
As a result, pain may return more quickly, require higher doses, or spread beyond the original sitedriving a cycle of escalating medication use without meaningful resolution (27,31)
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In most cells there are several enzymes catalyzing dehydrogenase reactions other than G6PD that produce NADPH, and therefore even when G6PD is deficient there may be no shortage of NADPH
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