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NIT-1 cells treated with PA + Ex-4 and PA + GW showed enhanced GSIS capacity, increased PPAR expression, decreased UCP2 expression and ADP/ATP ratio, and improved mitochondrial DNA content and mitochondrial membrane potential compared with those treated with PA alone, whereas the opposite results were observed in the PA + GSK group
Importantly, the reduction in LBM was modest relative to the overall BW loss, suggesting that GLP-1 RAs favor selective adipose tissue reduction over loss of lean tissue
In the STAIR XI meeting this point was made more explicit and recommended to be taken into account in the design of preclinical studies [25, 26]
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Levocarnitine ensures the mitochondria can meet that increased demand efficiently
After 8 weeks, there were no significant differences between groups in change of muscle strength
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