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It is also necessary for DNA synthesis and contributes to the framework of all physiological processes
Under physiological conditions, Nrf2 is regulated by cytoplasmic Keap1, an adopter protein for CULLI3-based ubiquitin E3 ligase that continuously ubiquitinates Nrf2 for proteasomal degradation
This hypothesis is also supported by our HIF-1 knockdown experiments, in which GLP-1R signalling-induced gene expression and metabolic adaptations were only partially perturbed, pointing to a possible involvement of additional transcriptional factors
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These biochemical characteristics make ocular neural tissues more susceptible to oxidative damage compared to the whole-body biological system
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