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Pharmacodynamics Onset of Action The pharmacodynamic profiles for TOUJEO given subcutaneously as a single dose of 0.4, 0.6, or 0.9 U/kg in a euglycemic clamp study in patients with type 1 diabetes showed that on average, the onset of action develops over 6 hours post dose for all three single doses of TOUJEO

Practical tips for thigh injection of retatrutide: Sit down with your leg relaxed and slightly extended Choose the outer front portion of the thigh, avoiding the inner thigh entirely Pinch the skin if you have less subcutaneous fat in this area Insert the needle at a 45 degree angle for leaner individuals, 90 degrees for those with more tissue Alternate between left and right thigh each week at minimum Avoid injecting within 4 inches of the knee or the groin The posterior upper arm: the clinical favorite The back of the upper arm is the third approved injection site for retatrutide

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SM significantly induced -endorphin expression and activated p38 mitogen-activated protein kinase signaling in the spinal dorsal horn and primary microglia