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Cobalamin deficiency results in the decrease of this conversion, resulting in high plasma levels of homocysteine, which is associated with a higher risk of cerebrovascular disease, depression, dementia, cellular stress, and apoptosis (25, 27, 64, 70)
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5-LOX is a dioxygenase similar in structure to other lipoxygenases and contains an helix catalytic domain that contains non-haeme iron and an N-terminal domain, which bind to calcium and zwitterionic phosphatidylcholine in membranes (but not cationic phospholipids) and are indispensable for its activity
10.4103/1673-5374.259617 69 LiC
As erythrocytes lack intracellular organelles, their metabolism is restricted to well-known cytosolic biochemistry: glycolysis, the pentose phosphate pathway (PPP), redox metabolism, oxygen metabolism, purine/nucleoside metabolism, and membrane transport
Tirzepatide levels fluctuate throughout the week, and some blood markers are more affected by these fluctuations than others
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