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Low-dose phthalates promote breast cancer stem cell properties via the oncogene Np63 and the Sonic hedgehog pathway
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Side Effect Management: For those particularly prone to nausea or other gastrointestinal issues, a more gradual or carefully adjusted titration, as guided by a healthcare provider, can make the difference between successful adherence and early discontinuation
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the use of pro-GSH molecules (Fraternale et al., 2006) and/or glutathione precursors like N-acetyl cysteine (NAC), glutamine, cysteine (cystine) and glycine, as well as nuclear factor erythroid 2 p45related factor 2 (Nrf2) inducers like sulforaphane can enhance glutathione production and increase nuclear Nrf2 translocation and antioxidant response element (ARE) transcription (Komaravelli and Casola, 2014
