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Gwyer and colleagues (Cell Tissue Res, 2019) provide a comprehensive review of the musculoskeletal literature

At the same time: most peptide therapies discussed for injury recovery are still considered experimental and have not yet reached the level of evidence required for routine clinical use

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intravenous TB-4 Phase 1 safety and pharmacokinetics, no dose-limiting or serious adverse events (Ann N Y Acad Sci 2010;1194:223229): NCT00743769 Centers for Disease Control and Prevention

| | 5-Amino-1MQ Monotherapy | None | 50100mg daily | Daily oral or subcutaneous | NNMT inhibition preserves NAD+, activates AMPK and mitochondrial fat oxidation | 812 weeks | Promising preclinical data

If you find yourself forgetting things more than usual or struggling to stay sharp, a B12 injection could make a noticeable difference within days