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Drugs targeting multiple parts of the BP reflex pathway causing OH may carry cumulative risk, suggesting that individuals with polypharmacy could benefit from routine postural BP monitoring
A., Sakatani, T., Sugamura, K., Makino, M., Ito, H., Savaraj, N., Kaibara, N., and Kuo, M
It should be noted as well that impaired metabolism and mitochondrial dysfunction were also suggested to occur in other psychiatric disorders such as bipolar disorder [144, 145], major depressive disorder [146] or autism [147]
This fundamental difference explains why DSIP users rarely report the morning grogginess common with conventional sleep aids
Even in this narrow population, a provider must weigh adding a second agent against switching to the more potent dual-mechanism drug or optimizing current therapy
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