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[3] Intramuscular injection, or more specifically peri-lesional injection near an injured tendon or joint, has been used in animal models to test whether local delivery produces superior effects compared to systemic dosing
sALS and fALS share several features, including protein aggregation, motor neuron hyperexcitability, trafficking defects, disruption of nucleocytoplasmic transport, oxidative stress, mitochondrial dysfunction, glutamate excitotoxicity, and neuroinflammation
10.2174/1381612823666170220163219 123 SikiricP.SeiwerthS.RucmanR.KolencD.VuleticL
Kim KY, Kim DS, Lee SK, Lee IK, Kang JH, Chang YS, Jacobs DR, Steffes M, Lee DH
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