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In addition, small molecule inhibitors including SLC7A11 inhibitor HG106 and GCLC inhibitor buthionine sulfoximine (BSO) were introduced to investigate their effects on ROS, GSH levels and cellular viability in VRK2-KO and VRK2-KD cells, and the results were consistent with the above knockdown experiment (Fig

Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity

A novel senescence-based prognostic model unveils tumor interactions and drug resistance in colorectal cancer

Glutathione is a naturally occurring antioxidant produced in our cells

Another important case is the use of glycolytic 3-phosphoglycerate as a precursor for the serine and glycine metabolism through the one-carbon cycle