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Oxidative stress refers to toxins produced inside the body, free radicals, and those from without, which are caused by the environment
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If you take a traditional glutathione capsule, much of the delicate tripeptide is broken down by your stomach acid and digestive enzymes before it ever reaches your bloodstream
10.3389/fpsyt.2021.554621 19
OXIDATION TOXIC PATHWAY (CYP2E1 enzyme) Only 5-10% of acetaminophen in healthy non-pregnant adults INCREASES by 80% during pregnancy[] Creates NAPQI (N-acetyl-p-benzoquinone imine)the toxic metabolite NAPQI formation 43% HIGHER in first trimester[] NAPQI must be immediately neutralized by glutathione When glutathione is depleted, NAPQI causes cellular damage Crosses the placenta and damages fetal brain HOW PREGNANCY CHANGES ACETAMINOPHEN METABOLISM METABOLIC PATHWAY CHANGES DURING PREGNANCY[] Human pharmacokinetic studies reveal dramatic shifts in how pregnant women metabolize acetaminophen: Oxidation to NAPQI (Toxic Pathway) INCREASES by 80% The Brookhuis et al
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