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Multiple cohorts and meta-analyses have reported elevated circulating levels of IL-6, TNF-, and IFN-, as well as increases in IL-1, IL-8, and acute-phase reactants (e.g., CRP) [90]

In rats, R -lipoic acid was more effective than S -lipoic acid in enhancing insulin-stimulated glucose transport and metabolism in skeletal muscle (110), and R -lipoic acid was more effective than R,S -lipoic acid and S -lipoic acid in preventing cataracts (111)

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The main cause of CKD-induced anemia is reduced output of erythropoietina protein that stimulates red blood cell productionfrom the kidneys

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