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The SURPASS-1 trial demonstrated significant improvements in glycemic control and substantial reductions in body weight with all three doses of tirzepatide (5 mg, 10 mg, or 15 mg) compared to placebo over a 40-week period
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805 The transcription factor yes-associated protein (YAP) promotes the transcription of NEDD4L, leading to the ubiquitination and degradation of ACSL4, and reducing cardiac ferroptosis and myocardial infarction size in I/R mice
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