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AOD-9604 should be avoided or used only under close medical supervision in certain populations
Dual molecule targeting HDAC6 leads to intratumoral CD4+ cytotoxic lymphocytes recruitment through MHC-II upregulation on lung cancer cells
Full FDA approval, by contrast, requires successful multi-phase clinical trials for a specific indication, which these peptides have not completed
Destabilises copper coordination and accelerates aggregation
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