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Transcription factor activity changes: GHK-Cu modulates activity of key transcription factors including NF-B (inflammation master regulator), AP-1 (stress response), Nrf2 (antioxidant response element activator), p53 (cell cycle and apoptosis regulator)
Differential gene scores from the 786-O CRISPR screen under ML162 treatment relative to untreated cells
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The low-specificity L-threonine aldolase LtaE, which cleaves several L-3-hydroxy--amino acids, like HTML, to glycine and a corresponding aldehyde and which may accommodate molecules larger than L-threonine in its large substrate binding pocket (di Salvo et al., 2014), may exhibit side activity as HTML aldolase
Their mechanisms and evidence bases are distinct
