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When reported, side effects for milk thistle are generally gut disturbances like diarrhea, nausea or bloating
These benefits appear to reflect both improvements in traditional risk factors - weight, blood pressure, lipid profiles, glycemic control - and potentially direct cardioprotective effects mediated by GLP-1 receptors expressed in cardiomyocytes and vascular endothelium
Counteracting tryptophan metabolism alterations as a new therapeutic strategy for rheumatoid arthritis
Though off-label use is allowed by the FDA, the medications have not been approved for these treatments and manufacturers may not promote or market the drugs for off-label treatments
So, it's a very bad outcome when it happens
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