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It is therefore important to keep in mind (1) the risk of over-basalization and (2) guideline recommendations that basal insulin therapy should be escalated to combination injectables when the basal insulin dose exceeds 0.5 Units/kg BW/day

Therapeutic applications and challenges in myostatin Inhibition for enhanced skeletal muscle mass and functions

In a large phase 2 trial involving 387 participants across 12 countries, weekly survodutide administration for 46 weeks produced dose-dependent weight reductions of 12.5% to 14.9% at doses of 2.4-4.8 mg [82]

The study concluded that there may be clinical benefit to the use of GLP1-RA in MCAS but as this was an observational study, there were no controls

Those with specific nutritional needs should discuss personalised protein targets with a registered dietitian or healthcare professional