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The Contraindication Is About Cancer, Not Hormone Levels Wegovy carries a boxed warning stating that in rodents, semaglutide causes thyroid C-cell tumors at clinically relevant exposures, and that whether it causes thyroid C-cell tumors including medullary thyroid carcinoma in humans has not been determined

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Most trials have not reported outcomes stratified by weight-loss achievement, nor have they incorporated mediatory analysis designs involving insulin clamps, hepatic fat content, or visceral adiposity

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