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The pattern across the preclinical record is consistent in direction angiotensin IV-derived analogs, including Dihexa in the independent Sun 2021 work, are reported to influence synaptic markers and maze learning in animals

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Abstract Scientists were chasing an incretin hormone, and when GLP-1 was finally discovered, we found that it had a pronounced satiety effect, slowed down gastric emptying, and actually reduced postprandial insulin response

This is interesting given that postprandial GLP-1 levels measured in the lymph are 56 times higher relative to sampling performed in portal plasma (36)