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The Kraus 2014 Nature paper established that NNMT is highly expressed in adipose tissue (especially in obesity) and that NNMT knockdown in adipose protects against diet-induced obesity in mice
This distinction matters clinically because it determines dosing, timing, and what results to expect at each stage of the protocol
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Biocatal Agric
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Use of CRISPR/Cas9-engineered INS-1 pancreatic cells to define the pharmacology of dual GIPR/GLP-1R agonists
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