Conservative protocol for beginners Goal: Assess tolerance and response before committing to full dosing Week 1: 50 mcg once daily (before bed, fasted) Week 2: 100 mcg once daily (before bed, fasted) Week 3-4: 100 mcg twice daily (morning and bedtime, both fasted) Week 5 onward: 100 mcg three times daily (if tolerated) This graduated approach allows researchers to assess their individual response to the appetite stimulation and any cortisol or prolactin-related effects before committing to full dosing
The Surmount-5 trial had 25% and 30% weight loss reported, and max tolerated dose of tirzepatide caused 36% and 22% of patient hitting those two marks respectively
The combination arm was terminated early due to severe adverse events and deaths, while NAC alone showed no significant effect on lung function, though secondary endpoints (6MWD, QoL) improved modestly (139)
Reported experience suggests that injury severity and how long the injury has lasted matter more than body weight
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