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By modifying the base molecular structure to resist rapid degradation by the DPP-4 enzyme, scientists have created a compound that remains active for significantly longer periods than native GLP-1

Clinical trials show berberine produces only modest weight reductions of approximately 2 to 4 kilograms, and many studies show little to no weight loss effect compared to the roughly 10 percent or greater body weight reduction seen with GLP-1 medications

Multiple studies demonstrate that higher body mass index (BMI) correlates with increased psoriasis severity, greater body surface area involvement, and reduced response to systemic treatments including biological therapies

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