SURMOUNT-5 Trial Tirzepatide vs Semaglutide Head-to-Head, NEJM May 2025 2
, fvrier 2002, 282(2):E474-82 Paolo Colombani, Caspar Wenk et Iris Kunz, Effects of L-carnitine supplementation on physical performance and energy metabolism of endurance-trained athletes: a double-blind crossover field study , European Journal of Applied Physiology and Occupational Physiology , vol
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Key risk factors include: Rapid weight loss: Losing weight quickly significantly increases gallstone risk Female sex: Women are two to three times more likely to develop gallstones than men Age over 40 years: Gallstone prevalence increases with age Obesity: Higher baseline BMI correlates with increased risk Previous history of gallstones: Prior biliary disease predicts recurrence Family history: Genetic factors contribute to gallstone susceptibility Certain ethnicities: Native American and Hispanic populations have higher baseline rates Estrogen exposure: Oral contraceptives, hormone replacement therapy, and multiple pregnancies Diabetes and dyslipidemia: Metabolic conditions affecting bile composition Prolonged fasting or TPN use: Reduces gallbladder contraction Patients should be educated about warning signs that may indicate gallstone complications
just 2.7% of the Zepbound group dropped out of the study early, compared to 5.6% of people on Wegovy