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The cholesterol content in each fraction was determined using an enzymatic cholesterol assay kit (ab65390, Abcam) per the manufacturers instructions
In addition to the results from SURPASS 4, which was designed to provide preliminary evidence for the cardiovascular safety of tirzepatide, a separate analysis pooling all the clinical trials with tirzepatide was used to generate a pre-specified estimate of cardiovascular events [20] (Table 1)
Current data are insufficient to establish definitive conclusions regarding translational relevance, safety parameters, or functional outcomes
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Major drug Interactions: MAO inhibitors will increase effects & toxicity Notes: Schedule II drug with high abuse potential References: Babiskin AH, Zhang X (2015): Application of Physiologically Based Absorption Modeling for Amphetamine Salts Drug Products in Generic Drug Evaluation
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