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The cyclical dosing protocols used in research (short cycles followed by long breaks) inherently limit total exposure
11:07 Cellular Delivery Science Dr
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Liposomal delivery is designed to solve the problem of poor absorption
Subcutaneous and intraperitoneal routes give shorter circulating windows, with the compound clearing primarily through proteolytic degradation outside the GI tract rather than through renal or hepatic elimination as a single molecule
PMID: 11116208 Wu Z, Ng FM
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