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That said, peptide bonds and certain side chains can still undergo slow chemical degradation over time, accelerated by light, heat, and oxygen exposure

A conservative approach using 0.25 mg daily for the first two weeks allows assessment of individual response before considering increases

Treatments with the NOS inhibitor L-NAME and iNOS inhibitor GW274150 are proven to improve inflammation response, and a trend toward a reduction in synovial thickness is observed (154, 155)

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however, a protein called glucocorticoid-induced leucine zipper (GILZ) may be involved