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Before obvious clinical symptoms appear in AD patients, increased BBB permeability occurs in many brain regions, including the hippocampus, cortex, deep gray matter, and white matter by Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) [146,147,148,149]
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doi: 10.1111/J.1398-9995.2009.02220.X 225 HollamsEMHartPHHoltBJSerralhaMParsonsFde KlerkNHet al