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The tapering approach essentially reverses the standard treatment protocol for GLP1s, which typically involves gradually increasing the dose over time

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Wu C-Y, Chen IH, Tong Y-C

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One example of such GPCR is the protease-activated receptor 2 (PAR2), which is specifically expressed in the plasma membrane of endometrium epithelial cells and modulates intracellular calcium levels upon activation by serine proteases like trypsin