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For signs of infection at the injection site (rapidly spreading redness, warmth, swelling, or pus) or systemic symptoms such as high fever, chills, or feeling severely unwell, contact NHS 111 or attend an urgent treatment centre promptly
The study investigators had final responsibility for the decision to submit the manuscript for publication
Evidence-based guideline: Treatment of painful diabetic neuropathy: report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation
Another limitation of GLP-1 RAs is that discontinuation commonly leads to substantial body weight regain, and many patients who regain weight subsequently restart GLP-1 RA therapy, resulting in a recurrent cycle of body weight loss and gain [10]
About the GEMINI-1 Clinical Trial The GEMINI-1 clinical trial was a multi-center, randomized, double-blind, placebo-controlled Phase 3 clinical study (NCT06396429) conducted by Hengrui in China to evaluate the efficacy and safety of HRS9531 injection in adults (18 years of age) with obesity (BMI 28 kg/m 2 ) or overweight (BMI 24 kg/m 2 ) and at least one weight-related comorbidity without diabetes
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