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Given the growing body of evidence that has suggested a role for this receptor in cancer and other diseases, there is certainly room for the development of alternative targeted therapeutics and several approaches are in preclinical and clinical development (Figs
It also plays a critical role in maintaining cellular health by directly neutralizing free radicals, as well as by maintaining the activity of vitamins C and E
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The intracellular Km for carnitine, which is also important for understanding the mechanism of carnitine traffic has been measured only in proteoliposomes, an experimental system which gives access to the internal face of a transporter (Scalise et al., 2013)
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Plays a role in the immune system by detecting antigens and triggering immune responses against invaders
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