The MTHFR gene mutation leads to various health issues and understanding and managing this mutation is crucial for overall health
A cutoff value of 10.2 nmol/mg for GSH was identified, and the area under the ROC curve was 0.913, with a sensitivity of 90.2% and a specificity of 81.8%, demonstrating significant predictive capability in differentiating between the resistant group and sensitive group
Depletion of glutathione is commonly observed in neurodegenerative diseases like Alzheimer's and Parkinson's, contributing to neurodegeneration
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Furthermore, recent findings reveal that alterations in BBB and its transporters affect the entry of therapeutic drugs designed to treat neurodegenerative diseases (Zhang, 2025)