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Obesity-associated cancers include prostate, ovarian, breast (post-menopausal), colorectal, endometrial, and renal cancers [8]

LEADER, SUSTAIN-6, and REWIND trial outcomes The initial wave of cardiovascular outcome trials (CVOTs) predominantly focused on patients with type 2 diabetes at elevated cardiovascular risk

Miller et al., 2013) and AMPK-independent (Madiraju et al., 2014, 2018) pathways

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This review highlights NAD+ as a central regulator of energy metabolism, mitochondrial function, and cellular repair, demonstrating that age-related declines in NAD+ may contribute to chronic disease, while supplementation with NAD+ boosters shows potential for reducing age-related decline and disease