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In summary, the synthesis of melanotan peptide using chemical synthesis requires multiple chemical reaction and purification steps, and the reaction conditions and operating processes of each step need to be strictly controlled to ensure the purity and yield of the final product
At 24 weeks post-administration, the Donor+Cas9-treated mice showed a significant reduction in both food intake and body weight compared to the Saline group, with a 29% decrease in food intake and a 34% decrease in body weight
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