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Overall, GLP-1RAs have been shown to be effective in managing T2DM and have helped patients reduce HbA1c by 2% over the course of 18 months to reach levels below 7% [41]

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A placebo-controlled, double-blind, phase II clinical trial (the ELAD trial) testing liraglutide in over 200 patients with mild cognitive impairments/AD for 1 year showed that neuronal loss was reduced by the drug (Colin et al

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In addition, BCL2 levels were increased indicative of anti-apoptotic response in these cells after IGF-1 treatment (Fig