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An approximate 2- to 3-fold accumulation was observed in trough serum concentrations (Cmin 7.21) following 140 mg doses administered subcutaneously every 2 weeks or following 420 mg doses administered subcutaneously monthly (Cmin 11.2), and serum trough concentrations approached steady-state by 12 weeks of dosing

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With GLP-1 use, major adverse cardiac events decreased from 45.5% to 18.9%, and the median insulin need decreased from 50 to 27 units at the end of five years

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