glp-1 drugs metformin vs. Receptor Agonists: Which Diabetes Medication Is Right for You? Are GLP-1s and SGLT2s replacements

Moslemi Mehni N et al

Oocytes were first fixed in 4% paraformaldehyde and permeabilized using Triton X-100, followed by blocking in 1% BSA

These molecules were tested for DPP-4 inhibitory activity, with 6-methyl-5-(4-methylpyridin-2-yl)-1-phenyl-1H-pyrazolo[3,4-d] pyrimidin-4(5H)-one (compound 29) (Figure 5) showing the highest activity (IC 50 = 1.06 M)

10.1038/s41522-024-00477-w 51 LebherzC.SchlieperG.MollmannJ.KahlesF.SchwarzM.BrunsingJ.et al (2017)

For insect feeding and pathogen inoculation assays, plants were grown in soil for 45 weeks at 22 C with a 10 h/14 h light/dark (short day, SD) photoperiod

Combined with above-mentioned data, GLP-1RAs show a positive impact on the suppression of NLRP3 inflammasome (Figure 2)